Archive for the 'Medical News Bits' Category

The Low Cholesterol and Cancer Link…

July 27, 2007

Lowering the cholesterol level of any patient with risk for heart disease is very important.  It is a MUST for any patient with Diabetes or Hypertension. It is sometimes difficult to convince patients to take anticholesterol meds because many are so afraid of the link to liver disease rather than be afraid of the heart disease if cholesterol is not regulated.  Likewise, patient remains asymptomatic even with elevated cholestrol so the urgency to seek treatment is not there.

Now comes another story linking low cholesterol to cancer!!!!

The increase in cancer incidence among statin users was small — about one extra case per 1,000 people, according to the study in the July 31 issue of the Journal of the American College of Cardiology. Apparently the slight increase in cancer incidence was found in 13 trials among statin users who achieved the lowest LDL cholesterol levels.

Is This A Cause For Alarm?

Most likely NOT! Again this is only an observation among the 23 trials studied and NOT a Cause and Effect Situation.  This calls for more attention and further study but again just like any drug or intervention we do…If there’s an effect…there almost always a Side Effect!  If you take a drug based on a premise that it is so safe without side effects then you are in for the worst!  Most likely you were sold by the marketing strategy of the sales agent!

Remember… the economic burden of suffering from heart disease is more than the risk of getting cancer in this case.  Likewise the effect of lowering cholesterol and lowering ones risk for heart disease is PROVEN .  It is also possible that by postponing disability and death due to heart disease, we make people live longer and in population studies, the longer we live the more likely we will get other diseases and cancer is one of them!.

My Recommendation is for my patients NOT TO WORRY!

The benefits of lowering cholesterol continue to outweigh the risks! Continue taking the drugs and I will continue to implement the same strategy of aggressiive lowering of cholesterol to prevent the target organ of high cholesterol levels…The HEART!

Low Cholesterol Unlinks The Burden Of Heart Attack!

AACE Philippine Chapter Annual Convention

July 26, 2007

scan0001.jpgThe American Association of Clinical Endocrinologist – Philippine Chapter will hold its Annual Convention on August 10 to 12, 2007 at Shangrila Mactan.

All doctors of all specialties are invited to join the affair as the organization has prepared a well balanced sessions for great learning!  As the one in charge of inviting foreign speakers it was pretty tough but finally there will be 6 foreign speakers– all world renowned in their own field of interest who will join us in the event.

  • Dr Hossein Gharib of the Mayo Clinic , my friend and my great boss… a respected expert in the field of Thyroid Diseases ,who is also presently the President Elect of the American College of Endocrinology will talk of  FAQ on Thyroid Diseases and another symposium on Controversies of Thyroid Cancer.
  • DR Steven Petak who is the Past President of the American Association of Clinical Endocrinologist will talk on Updates on Osteoporosis as well as Vitamin D: Bone and Beyond.
  • Dr James Gavin of Emory University will talk about The new Drug for Diabetes called Byetta and a plenary on Diabetes in Pregnancy
  • Dr Cecil Lansang of California who will talk and teach participants on the Thyroid Ultrasonography;
  • Dr Melvin Tan from the National University of Singapore will talk on Diabetes and Hypertension
  • Dr JJ Mukherjee also from the National University of Singapore will talk on Updates in Endocrine Hypertension and Male Hypogonadism

Prominent Local Speakers will also be present:

  • Dr Augusto Litonjua of Makati Medical Center who will talk on the New Incretins and GLP1 drugs for Diabetes,
  • Dr Ricardo Fernando of ISDF on Advances in Diabetes Care,
  • DR Estrelle Lopez of UST on Nutrition and Diabetes and
  • Dr Gerry H Tan of Cebu Doctors’ University will talk on The Proper Use of Insulin in Diabetes.

Registration will be FREE for the Residents in Training from all hospitals.  For Consultants, it will be a nominal fee of only P500 for the 3 day affair.  Registration will start at 8:00 to 11:00AM on Friday Aug 10 with the First Luncheon Symposium on Insulin Therapy at 11:30AM to 1:30 PM. There will also be exhibits from our pharmaceutical partners.

This is an opportunity for fellow Cebuano Doctors and neighboring cities and provinces to take part in this grand affair where you will have the chance to ask your personal questions regarding your patients with the experts in the field of Endocrinology.

For questions…please call Dr Gerry H Tan at 032-412-4803 and Dr Marsha Tolentino at 032-412-2767.

Or you can write to me in this website for any inquiries….

Can Diet Coke Cause Heart Disease?

July 25, 2007

212693807.jpgI usually allow my patients to drink soda as long as it is a “diet” or “light” soda…meaning, no sugar added but the sweetness is plainly due to an approved sweetener.  I usually caution them to drink only 1 can a day and not more.  The only concern I have is the amount of sodium in the soda rather than it causing harm to my diabetic patients.  It is therefore rather surprising to me that a study published in Circulation July 24 issue came up with a warning that “drinking more than one soda a day — even if it’s the sugar-free diet kind — is associated with an increased incidence of metabolic syndrome, a cluster of risk factors linked to the development of diabetes and cardiovascular disease.”

The study is not the ideal study population or method that can come up with a firm conclusion or assoiciation since this is a population based study where more than 6,000 participants in the Framingham Heart Study were followed up since 1948.  The study found that after four years of the study, “people who consumed more than one soft drink of any kind a day were 44 percent more likely to develop metabolic syndrome than those who didn’t drink a soda a day.”

Theories as to why this happen are intriguing steming from the fondness of sugary foods among people drinking soda to the caramel content of the soda promoting metabolic changes in the body.  Unfortunately, this study only proves a possible association and cannot in itself infer causality.  In other words…There is no proof that soda in itself is the culprit until further studies on causality can be done.

So if you love soft drinks then I would recommend allowing yourself to enjoy a”diet” or a “light” soda and only 1 can per day.  Overconsumption of a certain food does not allow one to prevent a disease by consuming more of a certain beverage even if it deemed safe by the medical community.

So…Can Diet Coke Cause Heart Disease? 

I doubt it.  This is only an observational study.  The same kind of method that initially suggested that Estrogen hormone therapy can lower ones risk for heart disease but eventually when a randomized prospective study was done… hormone replacement therapy actually increased ones risk for heart disease. BUT the study for me tells us only one thing: that even if it is “diet and has zero calories does not mean it is safe to over indulge!

The American Heart Association continues to recommend low calorie beverage as a good option for a healthy meal and likewise issued a statement :

“Since this is an observational study, it is important to note that the study does not show that soft drinks cause risk factors for heart disease. It does show that the people studied who drank soft drinks were more likely to develop risk factors for heart disease.

“However, it is possible that other factors could explain this relationship. Often people who drink soft drinks also eat and drink more calories, saturated fat and trans fat and less fiber and dairy products. Also, these people tend to be less physically active. This was true among the subjects in this study.”

So for me … the verdict is in:

It’s the LIFESTYLE Not The Drink! 

Read My Other Related Posts:

Coffee Cuts The Risk To Develop Diabetes

July 24, 2007

3517174637.jpgAnything that we do as long as these activities dont harm us is worth enjoying.  If you love to drink coffee and enjoying your cup while reading your morning daily then this report is good news to you!!!

A recent study published in the Archives of Internal Medicine involving 28,812 postmenopausal women who were followed up for 11  years where 1,418 women developed diabetes… showed that postmenopausal women who drink coffee regularly decreased their risk  of developing type 2 diabetes by 22% compared to women who never drink coffee.  The risk continued to drop as ones coffee consumption increased!!!!

The researchers stressed “in light of the popularity of coffee consumption and the high rates of type 2 diabetes mellitus in older people, these new finding may be of significance from a public health point of view.”  But it is very important for us to remember that: the right diet and exercise continues to be the first line in preventing the onset of this chronic disease called Diabetes.

Is it the Caffeine? Or is it the Coffee itself that gave the protection?

The study found that the women in their study who consumed caffeine from other sources – not coffee – did not experience the same benefit as those who drank coffee.  Meaning it should be what is in the coffee that offered protection.  Likewise, women who regularly drink decaf experience an even lower diabetes 2 risk meaning it may not be the caffeine after all.

I am not depending on my coffee each morning to help me cut my risk to develop diabetes.  I do my own homework of eating right and doing my regular exercise BUT this report helps me enjoy my coffee even more!!!! And Lastly…I dont own a Coffee Shop…..

Double The Fun With Your Daily Coffee!

Read My Other Related Posts:

How Much Exercise To Prevent Diabetes?

July 23, 2007

imageswer.jpgExercise and exercise…we know its benefits.  But one thing that really makes me exercise is my risk to develop Diabetes.  We know we can prevent this disease by behavioral therapy like taking care of ones diet and physical activity but doing the exercise for an hour can be TOO MUCH! A lot of friends buy the exercise gadget including the famous treadmill machine…but bet you, if I survey on this site how many of you out there has this machine but has no longer been used it for more than a year?  Any takers?

According to the U.S. Centers for Disease Control and Prevention (CDC) “one in three American children born in 2000 will develop type II diabetes!!!!” So parents take note: 1 in 3. As much as we want to pamper our kids for the lack of time we sometimes spend with them…be the parents or the grandparents who usually spoil these kids ( smile)  with candies, burgers and ice cream… Be AWARE!

But there’s hope:  new study at the University of Missouri-Columbia says that acute exercise — as little as 15 minutes a day — can have a profound influence on preventing and fighting the disease.  That’s easy!!!! 15 minutes is definitely manageable to anybody and am one of those that finds this study rewarding to all of us who feel disappointed about the need to really do the workout for an HOUR! But for guys who just dont have the time…read my other article below this…

This exercise activity is not the exercise of daily living BUT an acute form of exercise which is a bout of activity in which people Actively Participate!!!.  Activities like running, walking or biking for straight 15 minutes!

Remember there is no limit as to the impact of exercise on this disease… it has been proven to be effective at all levels.  Whether you are still trying to ward off this disease because of obesity or you are already a diabetic on medications or even if you are already on insulin for several yearts, exercise can make a difference in improving your body’s response to insulin.

A bit of good news for this week folks!

Only 15 Minutes Of Exercise Can Make A Difference!

Read My Other Related Posts:

How To Live Longer Without Exercising!

July 20, 2007

3904728485.jpgBeing busy or too busy to exercise may not be bad after all….

A recent report from the Mayo Clinic may prove to be worth considering if we talk about the need to be more active to live long.  We all know the fact that increasing exercise not only prevents one from developing chronic illnesses associated with inactivity and obesity but also can make us feel better and live longer.

According to the March issue of Mayo Clinic Women’s HealthSource: marathon training or going to a gym is not required but by staying busy and active all day can do the trick.  Such activities that can help people live longer by expending more energy include household chores such as vacuuming, mopping the floor, washing windows, lawn work, caring for children or adults, walking or volunteering.

The study, published in the Journal of the American Medical Association, tracked 302 adults between the ages of 70 and 84 for six years.  The study showed that:

” Participants who had shown the highest energy expenditures due to more physical activities had about half the chances of dying of those with the lowest energy expenditures. Participants most likely to be in the high-energy group reported climbing stairs or working for pay as a daily part of their lives.”

There you go… being busy can mean healthier lives as long as people who are “too busy” for exercise,  can stay “too busy” around the house and at work, or in the community doing what they have to do and in return live healthier lives.

Great news to those busy bees…. just dont be geeks and be sedentary and “too busy” sitting in your chair facing your computers with only your fingers and mouths exercising.  Those activities dont count!

No More Excuses..Start Moving!

Do You Have A Family History of Diabetes?

July 17, 2007

1997049824.jpgI always counsel my patients to inform their siblings, relatives and kids regarding the potential risk to develop diabetes in their lifetime.  I often require my patients to bring their kids during their next visit so my counseling and education can be heard and have an impact several fold!

Recently, a study from the International Diabetes Institute, Melbourne, published in the June 19 issue of the journal Circulation has shown that even the very earliest signs of Diabetes can increase the risk of dying from heart disease.  The findings confirm our previous observations that by the time ones fasting blood sugar is increased: 50% of the patients have already signs and symptoms of complications including that of the heart.   Now comes this finding that tells us more: that many more people are at risk of suffering from the complications of diabetes — even BEFORE they are diagnosed with the elevated blood sugar.

One message therefore that this study gives us is:

Dont take any abnormality of blood sugar for granted.  Consider it serious form the very start because any amount of early intervention can mean a lot to ones risk of developing heart attacks and strokes.  Not anly are they disabling but more so a tremendous economic load especially treating the complications!

So whats a normal blood sugar? Anytime your fasting blood sugar exceeds 99 mg/dl is already abnormal! Anytime of the day if your blood sugar reaches 200 even immediately after a meal is already abnormal.  Anytime if your blood sugar 2 hours after a meal is > 140mg/dl is already a red flag!  Now once your fasting blood sugar exceeds 126 mg/dl…that’s Diabetes!

So Take action…if you’re at risk! The earlier you change your lifestyle …the better!

The Earlier We Intervene in Disease… 

The Better Outcome For Health!

Dont Reuse Takeaway Plastic Containers

July 16, 2007

imageser.jpgJust came from Malaysia to attend an emergency meeting for 2 days and while going through the Malaysian Daily read an interesting headline: Plastic Peril.

The main message of the headline was that since takeaway plastic containers are made to be used only once…make sure you dont reuse them nor use them to store your food!  These plastic containers apparently dont have the sturdiness and thermal stability that are present in reusable plastic containers. 

Similar recommnedations were given for plastic mineral water containers…not only is it difficult to clean, the stability of the plastic is also questionable considering the heat and humidity of Malaysia similar to our country.

The recommendations were based on the study done by the Faculty of Medicine, University of Malaysia where in 45 containers examined …at least one chemical was detected in all.  Although the chemical content was low…repeated exposure can result in accumulation of these chemicals esepcially one particle called BBP or Benzyl Butyle Phthalate which in the long run can cause endocrine function abnormalities involving the thyroid and the pancreas!

I am sure a lot of us have the practice of reusing these containers we get from the restaurants and reusing them in reheating foods in the microwave stored in the fridge.  Now we know this is not advisable nor safe!  So always remember…..

Reusing Takeaway Containers Is  Harmful To Your Health!

Too Little Sleep Because Of Work?

July 10, 2007

imagesslp.jpgIt’s not uncommon to party all night… study for our exams (especially when I was in Medical school) or staying awake late at night because of hospital duties OR as parents being awake all night with a sick child!  Whew… those were the times! 

 During these “Awake” periods our body tends to compensate by making us sleep more the next day…our bodies way of        ” catching up”.  These acute sleep debt or loses are not known to be harmful because our body is able to adapt to acute changes in life from sleep to emotions to hormonal changes.  What is not known until now is the chronic lack of sleep where we lose a little bit of sleep over a period of days, months or even years due to work and work and work!!!!!

Understanding the effects of chronic lack of sleep was recently published online by the Proceedings of the National Academy of Sciences (PNAS) from the group of Northwestern University.  In that study, the researchers discovered that “when animals are partially sleep deprived over consecutive days they no longer attempt to catch up on sleep, despite an accumulating sleep deficit.”  

The impact of these finding in humans is immense as experimental studies in humans showed that chronic partial sleep loss of even two to three hours per night was found to have detrimental effects on the body.  The effects include: impairments in cognitive performance, as well as cardiovascular, immune and endocrine functions.

The problem with these sleep-debt people is that they dont look sleepy nor report feeling sleepy BUT their performance on tasks was shown to decline.  Likewise, repeated partial sleep restriction in humans has been linked to metabolic dysfunction and cardiovascular disease.  In fact in our recent Endocrine Society Meeting, Sleep debt is now considered one major risk factor for Obesity and Diabetes!!!!

So how do we counter the effects of chronic sleep loss?

 Harvard Women’s Health Watch suggests: if you’ve missed 10 hours of sleep over one week, make up for it over the weekend and the following week. If you’ve missed sleep for decades, it could take a few weeks to repay the debt. Plan a vacation with a light schedule, and sleep every night until you wake naturally. Once you’ve determined how much sleep you need, factor it into your daily schedule.

So guys… it’s not bad to work and finish our tasks on time BUT if we overdo things to satify somebody even ourselves at the expense of our health…is something else!

Enjoy Your Work But Stay Within The LIMITS!

Obesity Surgery Can Help Diabetics Live Better Lives….

July 9, 2007

imagesobesir.jpgThe prevalence of Obesity and Diabetes is fast rising with an apparent increase of 60 to 70% within a 10 year period.  The relationship between the two is closely linked which brought a new disease state called: Diabesity or Diabetes plus Obesity!  Two major epidemics in one… result into TROUBLE!  They have the same major problem of lifestyle: improper food intake and plain inactivity and the same kinds of complications long term.

One magic bullet to hit two birds with one stone is the procedure called: Laparoscopic Gastric Banding.  This is a procedure that we now routinely perform in our institution with remarkable success.  It is a less invasive procedure than gastric bypass and has written about its procedure in one post in this website.  In a study done recently, not only did the procedure resulted in weight loss but likewise resulted in changes that reduced the culprit of developing diabetes , hypertension and high cholesterol: the Insulin Resistance State.

Below is the summary of the results of the study from the American Physiological Society Homepage

____________________________________________________________________________

   *      prior to surgery, there were expected gender differences in body composition measures. Men were heavier, had greater waist circumferences, and HbA1c( a measure of overall blood sugar control). Women had higher a percentage of body fat.

*      6months after surgery the overall group had a l5 percent reduction in body weight (275 vs. 233 pounds), a 14 percent reduction in BMI (43.4 vs. 37.3), a 13 percent reduction in body fat percentage (49 vs. 43 percent), a 13 percent reduction in waist circumference (53 vs. 46 inches) and a 10 percent reduction in hip circumference (57 vs. 51 inches).

*      six-months after surgery the insulin resistance was reduced 60 percent, according to a HOMA score. This was due primarily to a 50 percent reduction in fasting insulin concentrations with no change in fasting glucose concentrations.

*      there were a few gender differences in surgery-related changes. In women only, the waist-to-hip ratio tended to decrease (0.92 vs. 0.86), and the HbA1c tended to decrease (5.8 vs. 5.6 percent).  Diastolic blood pressured tended to decrease (81 vs. 75 mmHg) and CRP tended to decrease (8.3 vs. 4.7 mg/L).

__________________________________________________________________________

The findings are really promising.  If we reduce the state of Insulin Resistance by making a patient lose weight then we unburden our pancreas from over producing insulin in response to our meals. Likewise we therefore reduce a patients risk from developing chronic complications that can cause disability.

The authors concluded that:” These improvements occurred despite the fact that patients were still clinically obese. Rapid improvements in insulin resistance after surgery will have a positive impact on long-term patient health and may delay or prevent progression to diabetes.”

Behavioral Therapy remains the cornerstone of losing weight as well as managing diabetes.  If one can lose weight without invasive procedures through discipline with proper food intake and physical activity…the BETTER! 

But for weight loss remedy beyond the weight loss achieved by behavioral modification that may have lasting long term outcomes especially with regard to risks for chronic complications like heart disease and stroke…then

LAP Banding Is The Way To Go!

For further readings on Lap Banding: The Magic Way To Lose Weight

Are Your Kids Addicted To Video Games?

June 27, 2007

3788732059.jpgAny form of addiction from food to video games can be “life threatening”. You have heard stories of a kid having lost his life after losing a game online. And when the American Medical Association started to voice out specific concern to include Video Game Addiction as a disease means…it’s now becoming a problem!

According to the AMA council, “up to 90 percent of American youngsters play video games and as many as 15 percent of them – more than 5 million kids – may be addicted.”  Likewise, it further noted that: “dependence-like behaviors are more likely in children who start playing video games at younger ages.”

According to the Associated Press release:

Overuse most often occurs with online role-playing games involving multiple players, the report says. Blizzard Entertainment’s teen-rated, monster-killing World of Warcraft is among the most popular. A company spokesman declined to comment on whether the games can cause addiction.

The telltale signs are ominous: teens holing up in their rooms, ignoring friends, family, even food and a shower, while grades plummet and belligerence soars. The culprit isn’t alcohol or drugs. It’s video games, which for certain kids can be as powerfully addictive as heroin, some doctors contend.

So guys…beware.  Check your kids before it’s too late and before it becomes an Addiction!

Are Your Kids Playing Too Much Video Games?

The FDA Rules on Dietary Supplements

June 26, 2007

3847290624.jpgFinally!!!…The US FDA has made some firm stand on dietary supplements.  In the medical community it has been a puzzle as to why the health governing agency has always been hands off with regard regulating these dietary supplements!.  And how come nobody monitors the safety and the standards of this multibillion dollar industry.

The same goes with our local FDA and BFAD where supplements boast as being BFAD approved as if this is a tag to prove that the products are safe to be used by consumers.  You hear this on radio and you see these claims on print…Herbal Supplement is BFAD Approved!

So consumers beware because even if your supplements came from the US, the regulation of the sale of these products has not been standardized till now.  Toxic levels of certain substances present in your pill are not monitored nor are labels required… which at least for now is being changed!

Here’s more from the US FDA Fact Sheet:

 ___________________________________________

“The regulations establish the cGMP needed to ensure quality throughout the manufacturing, packaging, labeling, and storing of dietary supplements. The final rule includes requirements for establishing quality control procedures, designing and constructing manufacturing plants, and testing ingredients and the finished product. It also includes requirements for recordkeeping and handling consumer product complaints.“The final rule will help ensure that dietary supplements are manufactured with controls that result in a consistent product free of contamination, with accurate labeling,” said Robert E. Brackett, Ph.D., director of FDA’s Center for Food Safety and Applied Nutrition.

Under the final rule, manufacturers are required to evaluate the identity, purity, strength, and composition of their dietary supplements. If dietary supplements contain contaminants or do not contain the dietary ingredient they are represented to contain, FDA would consider those products to be adulterated or misbranded. The aim of the final rule is to prevent inclusion of the wrong ingredients, too much or too little of a dietary ingredient, contamination by substances such as natural toxins, bacteria, pesticides, glass, lead and other heavy metals, as well as improper packaging and labeling.The final rule includes flexible requirements that can evolve with improvements in scientific methods used for verifying identity, purity strength, and composition of dietary supplements.”

___________________________________________

We Need Stricter Rules On Dietary Supplements!

The Truth About Sex and Aging….

June 23, 2007

3046855028.jpgIt may be true that as we age, our sex life tends to deteriorate “literally”.  The frequency of sex may now be a factor due to more stresses in life both on the part of the husband and wife.  Likewise the notion that sex in older people is a “taboo” and not to be talked about is no longer acceptable.

Sex will always be a part of a good relationship.  And no matter how old, sex should be an essential element to a happy and healthy companionship.

The AARP recently in America held a survey on the topic Sexuality at Midlife and these are some of the interesting facts that came out:

  • 5 out of six respondents strongly disagree with the statement that “Sex is only for younger people.”
  • 6 out of 10 people considered that sexual activity is indeed a crucial part of a good relationship.
  • 10% of adults accepted the fact that they don’t particularly enjoy sex
  • 12% agreed never having sex again would be okay!
  • For the majority, the results from the study show that sexual activity is a critical part of a good relationship, and that a satisfying sexual relationship is an important factor affecting quality of life.

We have to accept the fact that as our body changes with age, so do the changes of sexuality follow.  Hormanal changes that occur especially with the declining testosterone levels in men resulting in loss of desire and erectile dysfunction as well as in women resulting in the loss of libido all contribute to the decline in sexuality.  But the good news is… there are now ways to address these medical needs so as we can continue to enjoy this one thing in life that is free and enjoyable!

Live stress as part of ones life and not let it deter you to enjoy sex.  If your mind is so preoccupied with the other thoughts then the pleasure from sex will be lost and depression can set in.  Stress maybe unavoidable but solving the problems besetting us should be done outside the bedroom!

There’s  no age limit to enjoying sex…there’s no limit to the frequency of sex.  Enjoy every minute of it and just have FUN!

Living and Aging Graciously Equates Wonderful Sex! 

Cancer Cases Are Rising…..

June 20, 2007

imagescancer.jpgThis alarm comes not as a surprise to me.  I got hold of this news release from the Associated Press which I want to share just to make us all wake up and think twice before we eat, and before we plan things in our lives…..

___________________________________________________________________________Longer Longer life spans and changing diet and lifestyles are among the factors that could lead to a dramatic increase in cancer cases in Asia by 2020, experts attending a conference in Singapore warn.If current trends continue, the total number of new cancer cases in Asia could climb from 4.5 million in 2002 to 7.1 million in 2020, the Associated Press reported.That increase could cause a major health crisis as poorer Asian countries struggle to pay the cost of cancer screening, vaccines and treatment, the experts said.“This will put a tremendous burden on patients, their families and the health-care system in each country,” said Singapore Health Minister Khaw Boon Wan, the AP reported.Smoking is a major cancer threat. In a number of Asian nations, more than 60 percent of males smoke, said Dr. Donald Max Parkin, a research fellow at the University of Oxford’s Clinical Trial Service Unit and Epidemiological Studies Unit.In many Asian nations, large numbers of people have moved from rural areas to the cities. That switch has led to more sedentary lifestyles, increased consumption of meat and fried foods, and fewer vegetables in the diet._____________________________________________________________________________

Havent you noticed that whether we are talking about Obesity, Diabetes or Hypertension… and now The Big C, the modifiable risk factors are all the same…The Lifestyle!  It may be a challenge to change the urban lifestyle but any chage for the better is worth the package! 

 

Changing Habits for the Better Means A Healthier Lifestyle!

The Life Expectancy of a Diabetic…

June 16, 2007

imagesrtyui.jpgI was reading through several articles today and one study that struck me is one that calculated how long a diabetic can live.  It is known that a diabetic patient is at risk of developing heart attack in his lifetime but how about the effect of diabetes on how long a diabetic can live.

It is known that being a diabetic increases ones risk to develop heart disease. In this study, having diabetes was shown to significantly increase the risk of developing cardiovascular disease (hazard ratio 2.5 for women and 2.4 for men) and of dying when cardiovascular disease was present (hazard ratio 2.2 for women and 1.7 for men).  Suggesting the need to be vigilant in targeting the prevention of the different risk factors that will increase this risk. 

The author of the study which was published in the June 11, 2007 issue of Archives of Internal Medicine also said it straight to the point in heartwire: “We showed that diabetes cuts out about eight good years of your life. While diabetics and nondiabetics have a similar number of years with cardiovascular disease, the disease process starts earlier in diabetics.

 Effect of diabetes on life expectancy with and without cardiovascular disease at age 50 years (men)

Life expectancy (y) Without diabetes With diabetes
Total life expectancy 28.8 21.3
Life expectancy with CV disease 6.8 7.1
Life expectancy free from CV disease 22.0 14.2

Effect of diabetes on life expectancy with and without cardiovascular disease at age 50 years (women)

Life expectancy (y) Without diabetes With diabetes
Total life expectancy 34.7 26.5
Life expectancy with CV disease 6.6 6.8
Life expectancy free from CV disease 28.0 19.6


The above table shows that a diabetic at 50 cuts his life expectancy by 8 years!!!!

The study authors explained this finding that :” diabetic patients reach the final stages of the movie prematurely by missing out on some of the best bits in the middle.” These findings underscore the importance of diabetes prevention for the promotion of healthy aging. Toward this end, it is essential to implement global strategies to change the current Western lifestyle and to promote the adoption of physical activity and healthy diets.”

The fundamental objective of everyone therefore at risk of developing Diabetes is to implement strategies of lifestyle changes that can reduce ones risk to develop the disease…. meaning…

Prevention Is The Key To Long Life Span!

Check Out My Other Related Posts:

Sleep and The Risks of Obesity and Diabetes…

June 9, 2007

One of the highlights of the Endocrine Society meeting that I attended just this week in Toronto Canada was  a plenary session on Sleep Debt and the Risk of Diabetes and Obesity

While reading Canada’s daily newpaper, the headline was that… companies are now allowing their workers also to take a nap in between work schedules with nap stations in their offices to allow workers to relax and sleep and be more productive as a result.  Suggesting that sleep debt is actually affecting productivity in the work place!

BUT how much sleep is healthy? or how many hours of sleep are needed to reduce diabetes and obesity risks? 

The magic number is 7 hours!!!

A study published in Diabetes Care this March of 2006 showed that  men who got little sleep (< 7 hours ) or a lot of sleep (8-10 hours) were more likely to develop diabetes than men with 7 hours of nightly sleep.  The same token people with less than 7 hours of sleep have a 23% to 73% increased risk of obesity!

But quality of sleep is also as important. Deep sleep is a must.  Even 7 hours of light sleep may do no good but harm.

Again the stress hormones may be responsible as more activation of the sympathetic nervous system resulting in overproduction of cathecholamies may be result in the increased risk.  Likewise, obesity may follow if you sleep less because you easily feel hungry and you tend to eat more if you’re awake!

So…..

Sleep Well and Be Well!

The Truth Of The Avandia Scare…

May 31, 2007

imagestel.jpgMy phone never stopped ringing …literally!  Apparently the NEJM publication caught the media in a frenzy mood!  The headline noting the increased risk of heart attack with the use of Avandia brought about the public scare and the panic.   This is one case to point where everything written in a well respected journal should be studied, scrutinized and reviewed before offering to the media to be sensationalized!

The real inside story however was never told as to why there was a need to rush the publication coupled with a sensationalized editorial.  Below is The  Wall Street Journal Commentary which I want to share with the readers and my patients as well…. 

As medical information is exploding and becoming more accessible, all of us, particularly physicians, need objective sources to interpret data and present a balanced view. Unfortunately, major medical journals that should be filling this role often put more weight on pushing political agendas.

Their editorial prejudice has left a troubling void for rigorous and unbiased arbiters of medical evidence who can guide sound medical practice decisions.  The behavior of the New England Journal of Medicine (NEJM) is a case in   point, when it rushed onto its Web site a limited and flawed analysis of safety concerns around the diabetes drug Avandia. The publication was timed to get ahead of the Food and Drug Administration’s more careful evaluation of the same issues. The journal seemed bent on beating the FDA to the punch. The goal? Painting the FDA as impotent, in order to argue for legislation winding through Congress that would increase regulatory hurdles for drug approvals. The journal’s motives were made bare by its own editorial on the matter.    

While there are “questions” whether Avandia is associated with certain heart risks — so far unsupported by more rigorous, randomized studies   and  extensive review by the FDA and other authorities around the world — the NEJM study doesn’t add much new insight into those issues because of its own limitations.   But you wouldn’t know that from the way the Journal hyped its analysis to the media or opined about the study’s significance. These facts weren’t lost on clinicians and even NEJMs competitors. The Lancet,  NEJM’s British sister-publication, said of the study, “Alarmist headlines and confident declarations help nobody.” A top American medical researcher  told WebMD, “I can’t help but wonder if the NEJM is functioning more like the mainstream press than a scientific journal at this point.”
      
 The paper which re-analyzed the results of 42 earlier studies of the drug found on the Internet, revealed that Avandia might cause a small increase in the absolute risk of a heart attack. But the study that the authors did, called a”meta-analysis” because it aggregates results from lots of studies to generate a larger sample, contained a number of serious limitations.
 

Among other things, the authors of the NEJM study based their conclusions that Avandia caused a higher heart risk on just a handful of cardiac events, none of which they could go back and verify, because, unlike the  FDA, the authors didn’t have access to confidential patient records

Dr Goetlleib who wrote the commentary further noted that….Absent was any discussion by NEJM of the drug’s benefits, or advice  from  diabetes experts on how doctors should counsel their patients based on the  information.

So Better Be informed Before We Judge!

Do You Need To Stop AVANDIA?

May 28, 2007

images.jpgMy email alerted me on this headline regarding the alarming news on a most commonly prescribed drug for diabetes called rosiglitazone or Avandia manufactured by GSK and the apparent increased risk of heart attack among those taking the drug! 

The problem is: New England Journal of Medicine article was only a meta-analysis of different articles that studied the drug but not with cardiovascular diseases as a primary endpoin.  The RECORD trial which will be available in 2009 is the ONE that we have to wait to fully answer the question of avandia and the risk of heart disease.

The comments of different societies complement my thoughts of the safety of this drug…meaning for me…the benefits continue to outweigh the risks.  I am a prescriber of this drug because it really helps my patients get into control, lower the rquirements for insulin with beneficial effects in protecting and preserving beta cells and therefore delays the progression of the disease.  This for me is important if we want to prevent long term complications.

1. Lancet‘s response to the NEJM article (23rd May) entitled “Rosiglitazone: seeking a balanced perspective.”

The editorial
criticises the NEJM publication
– states that the’ two most reliable studies to inform decision-making’ currently available are ADOPT and DREAM
– acknowledges that, although the recent NEJM meta-analysis (based on a small no of events) raise a signal of concern, before the results of RECORD are available it would be premature to overinterpret a meta-analysis

The editorial concludes by saying

To avoid unnecessary panic among patients, a calmer and more considered approach to the safety of rosiglitazone is needed. Alarmist headlines and confident declarations help nobody

2.The European Medical Association (US FDA counterpart in EU) recommends that, in EU markets, ‘patients are advised not to stop treatment with rosiglitazone and to discuss the medication with their doctor at their next regular visit’. societies:

Statement from US organisations
http://diabetes.org/diabetesnewsarticle.jsp?storyId=15115339&filename=20070521/comtex20070521pr00004113diabetesavandiariskEDIT.xml

Statement from Canadian Diabetes Association
http://www.diabetes.ca/section_main/newsreleases.asp?ID=194

Statement from Diabetes Australia
http://www.diabetesaustralia.com.au/notice_board/mediacentre.htm#NEJM

Statement from Diabetes UK
http://www.diabetes.org.uk/About_us/News_Landing_Page/Rosiglitazone-heart-attack-risk-not-cause-for-alarm/

Lastly, a fellow blogger Kevin MD had his thoughts on this and pointed out Dr Steven Haffners comments in his post:

Dr Steven Haffner (University of Texas Health Science Center, San Antonio), who was involved in the ADOPT study of rosiglitazone, said the paper needed to be published, but it should have undergone a more extensive review, and there should have been a different editorial with more emphasis on the flaws of the study. “The NEJM was irresponsible to go to [Drs Bruce] Psaty and [Curt] Furberg for the editorial–they were always going to emphasize concerns about drug safety; that’s what they do,” he commented. “But I’m not surprised this paper was published like this. The three major medical journals are becoming more like British tabloid newspapers–all they lack is a bare-chested woman on page 3,” he jibed.

For me….I will continue to believe in this drug as one helpful arm in my quest for a better treatment regimen for my patients with diabetes. The NEJM article is not the perfect study we look for to answer the questions of safety.  A Meta-analysis has its flaws which will be corrected by future proscpective studies with cardiovascular disease as a primary endpoint.

If you have your doubts… talk to your doctor.

If you believe in the drug and your doctor asked you to stop it based on NEJM article and its editorial …talk to a Specialist!

The Editorial of the well respected Lancet says it all:

Alarmist Headlines and Confident Declarations Help Nobody

Knowing Your BMI Means Taking Action To Be Healthy….

May 23, 2007

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This is an important chart for everyone to keep just to trace where our BMI is going! Up or Down! 

The International Obesity Task Force also came up with standards to follow for the Asia Pacific Region which calculates a lower BMI for the Asian population as overweight and obese

Why do we need to know our BMI? Because it calculates your health risk.  And more importantly, this tracks your progress in losing weight and therefore for every one point drop in BMI translates to a concomitant reduction for its associated disease risk especially early mortality….  Studies have shown that: if you’re obese your risk to die early is high! 

Remember…

Knowing the Numbers Means Wellness…

Read My Other Related Posts:

Can Fruits Cause Obesity?

May 15, 2007

imagesfrd1.jpgWe love fruits.  Being a natural source of sugar, we believe it is harmless in most ways. In fact you may have heard friends who tell you that they lose weight because they are on a fruit diet!  But too much of a good thing can turn out bad especially if over-consumption becomes a habit rather than an exception.

Recently though, the notion that fruits is generally okay has been challenge especially in the field of obesity.  Apparently, in animal studies, researchers from the University of Florida have found that fructose tricks your brain into thinking that you are hungrier than you truly are, causing you to eat more to feel satiated. The pathway at which fructose may be responsible for the rising epidemic of obesity is published in Nature Clinical Practice: Nephrology.

While it is common knowledge that the common causes of obesity includes the intake of high-fat, high-calorie foods and forgoing exercise, the concept of fructose as one culprit has never been on top of the list to determine if this sugar is in fact an underlying cause of metabolic syndrome, a condition that is linked to type 2 diabetes and obesity.

Fructose is present in many foods that we eat including the high fructose corn syrup to soft drinks, the jellies our children love , the pastries,  the tomato or banana ketchup and other commonly used products.  It is estimated that fructose consumption has risen more than 30 percent since the 1970s which coincided with the rise in the rate of metabolic syndrome and obesity worldwide.

But can fruits cause obesity? No link of that yet but again… eating a balanced meal with a fruit serving per meal should not make one gain weight MORE than the benefits of fruit consumption you’ll get!  But the general rule on fruits is: The Sweeter…The More Fructose…The More Calories!One Fruit Per Meal Is The Deal!