Archive for November 27th, 2007

Vitamin E and Heart Disease Among Diabetics…

November 27, 2007

Vitamin E has received a lot of good news and bad news. Now you read it being the antioxidant of choice in one study…then the next…it shows the opposite result.  Majority of these studies however are epidimeological and observational in nature and not well controlled prospective studies.  The HOPE and NIH studies were prospective studies that did not show positive effect of Vitamin E on heart disease.

Recently a new data on the possible important role of Vitamin E came about in a new prospective study which is worth looking published in the Journal Atherocsclerosis, Thrombosis and Vascular Biology….

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Methods- 1434 DM individuals  55 years of age with the Hp 2-2 genotype were randomized to vitamin E (400 U/d) or placebo. The primary composite outcome was myocardial infarction, stroke, and cardiovascular death. At the first evaluation of events, 18 months after initiating the study, the primary outcome was significantly reduced in individuals receiving vitamin E (2.2%) compared with placebo (4.7%; P=0.01) and led to early termination of the study.

Conclusions—Vitamin E supplementation appears to reduce cardiovascular events in individuals with DM and the Hp 2-2 genotype.

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Since 40% of our diabetic population has the Hp 2-2 gene…It’s probably about time for us to rethink whether all diabetics should take Vitamin E or not…

However the bottom line is:  more studies need to be done and outcome studies to support this new finding!

Vitamin E Is Worth a Second Look!