BYETTA and Weight Loss

August 18, 2007

imageslo.jpgExtensive research is being done in the field of Diabetes. The prevalence of this disease is just increasing worldwide and expected to reach 333 million by year 2025.  The scary thought coupled with difficulty in getting drugs invented and approved can make this a big epidemic in the future.

As new drugs come…some are worth it some are not.  The avandia scare made everyone realized that any drug no matter how great will always have side effects.  Any avandia taker should have realized that any patient with heart failure should not take the drug because it can worsen the condition.  

So what’s with this new agent called Byetta?  Is it all worth the hype?

Discovered from the Saliva of a Gila monster…Exenatide (Byetta) was just recently approved by the Food and Drug Administration in April 2005 for the treatment of type 2 diabetes. It was just recently launcehd in the Philippines. It is to be taken as an injection but although it is an injection, Byetta is not insulin!!!

Byetta improves blood sugar control by mimicking the action of the hormone incretin called GLP1 which allows insulin to work more effectively in the body.  The good thing with Byetta is that it also helps in preventing the further destruction of the Beta cells which are the cells that produce insulin.  It is this defect that remains unabated by current medications that will make a patient require insulin in the long run.  Now we have drugs that are proven to help prevent these cells from deteriorating including Rosiglitazone, Pioglitazone and now Byetta.

What is the Major Side effect of Byetta that as endocrinologist and patients alike like? It’s the WEIGHT LOSS! Finally we have a good drug that does not make a patient gain weight but instead lose weight. Its the downside that’s actually a PLUS! A weight loss of around 10 to 12 lbs can be achieved and sustained long term. A report from the New York Times mentioned about a patient who lost 60 lbs after Byetta use…  BUT… dont use this drug as a weight loss agent because this has not yet been studied for that purpose and the safety of this agent for non diabetics is not yet known.

Cost however is pretty prohibitive so better discuss this option with your doctors to assess benefit cost ratio.

Do I recommend this drug?  Yes I do and have started using this agent already. It was just recently launched at the AACE Philippine Chapter meeting in Shangrila and few doctors have been given the privilege to start using this drug for their patients by Eilly Lilly.  Its something new and revolutionary thus am writing about this in my website.  The New York Times Calls It: The Ray of Hope

For more information on Byetta: check out this site: www.byetta.com

The Gila Monster and the Man in Byetta!

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19 Responses to “BYETTA and Weight Loss”

  1. Lito Says:

    Heard about it Doc in the news. How do I know doc that I am a candidate of this drug? My blood suagr now on metformin is 187. I am overweight doc.

  2. Doc Gerry Says:

    One can combine this agent with either metformin or your present agents. Definitely this will be helpful for you because you will also lose weight with it. But better still talk with your specialist if you can be started on this.


  3. Great, great commentary!

    A very informative one too. My deepest, deepest appreciation!

    Go Byetta!


  4. Thanks, I enjoyed reading your post. Its nice to see someone writing something worth reading. Take care.

    – Jack

  5. Jeanny Santos Says:

    Hi Doc’ I was recently accidentally diagnosed with type 2 DM and was given Byetta 5 need to use it 2X a day so I am almost done with my first Byetta pen, when I checked at mercury drug store they dont have the exact brand but something a like? and it costs arround 10,650 something, Byetta was like 12,500 it is cost a lot. Do you know where I may purchase it at its most favorable price? or is there a substitute for it? I have lost relatively 20lbs to this day. I just could not afford it to sustain using it. My doctor described me being mobidly obese I am at 350 lbs now 5’4 in height. Please reply.=)

  6. Kendrick Says:

    Hi mate happy blogging now and continue posting valuable info

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  8. isa Says:

    how many mcg of byetta is injected daily when used for weight loss and how many times a day?

  9. olly Says:

    I should really be exercising. But I can’t leave this blog

  10. Mocity Says:

    Is there any new information on this drug?

    I have been prescribed it for weight loss but haven’t started it yet.

    • Doc Gerry Says:

      Its a prefectly fine drug and Ive been using it for my patients without any problems. A long acting preparation is most likely availabel in your area


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  12. Elizabeth Parker Says:

    Hi- I have been diagnosed with insulin resistance and hypothryoidism. My doctor put me on Byetta and admitedly the first few weeks were rough. I had severe nausea which lasted for about 2 hours after the injection, although over time the nausea completely went away.

    Byetta worked really well for me for weight loss. I lost 20 lbs that I have been fighting (without success) for several years. it was like a miracle in that the weight just melted off.

    the problem is that after a yea, r the Byetta stopped working and now the weight is back. Have you heard from other people that Byetta stops working and do you have any suggestions as to what a good follow – up med may be or how to restore sensitivity to Byetta?

    Thanks,
    Liz Parker

  13. donna browne Says:

    hello i have just started using byetta along with my other meds. my dr, gave me free pen for a month. it is working i really can tell, i have check with my pharm. i will not be able to buy it even with my ins, it is going to cost is there any coupons or how can i get it cheaper. so far i am impressed.
    thanks donna

  14. miranda chambers Says:

    hello i have been taking byetta a few months I was wondering should i keep byetta in the fridge after its open please let me know,

  15. mary Says:

    I was told no refrigeration after it’s open

  16. Kartik Says:

    Please keep it in the fridge always except while taking the dose. Instructions clearly mention to keep between temperature 2-8 C

  17. James E. McCollam Says:

    My endocrinologist has recommended Byatta. I am overweight but not obese. My A1Cs have been consistently in the 6’s, & last 5.7. It will cost me $111.00 for 3mos. of Byetta. With the small amount of weight loss in clinical studies is it worth paying the price since I am already under control? I’m on insulin with little or no pancreatic insulin production. I’m also taking metformin. Thank you for your response.


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