Are All Sugars The Same?

January 11, 2013

Unfortunately not.

This new study published in JAMA shows that fructose intake may not give the feeling of fullness compared to intake of other forms of sugars.




Increases in fructose consumption have paralleled the increasing prevalence of obesity, and high-fructose diets are thought to promote weight gain and insulin resistance. Fructose ingestion produces smaller increases in circulating satiety hormones compared with glucose ingestion, and central administration of fructose provokes feeding in rodents, whereas centrally administered glucose promotes satiety.


To study neurophysiological factors that might underlie associations between fructose consumption and weight gain.


Twenty healthy adult volunteers underwent 2 magnetic resonance imaging sessions at Yale University in conjunction with fructose or glucose drink ingestion in a blinded, random-order, crossover design.


Relative changes in hypothalamic regional cerebral blood flow (CBF) after glucose or fructose ingestion. Secondary outcomes included whole-brain analyses to explore regional CBF changes, functional connectivity analysis to investigate correlations between the hypothalamus and other brain region responses, and hormone responses to fructose and glucose ingestion.


There was a significantly greater reduction in hypothalamic CBF after glucose vs fructose ingestion (-5.45 vs 2.84 mL/g per minute, respectively; mean difference, 8.3 mL/g per minute [95% CI of mean difference, 1.87-14.70]; P = .01). Glucose ingestion (compared with baseline) increased functional connectivity between the hypothalamus and the thalamus and striatum. Fructose increased connectivity between the hypothalamus and thalamus but not the striatum. Regional CBF within the hypothalamus, thalamus, insula, anterior cingulate, and striatum (appetite and reward regions) was reduced after glucose ingestion compared with baseline (P < .05 significance threshold, family-wise error [FWE] whole-brain corrected). In contrast, fructose reduced regional CBF in the thalamus, hippocampus, posterior cingulate cortex, fusiform, and visual cortex (P < .05 significance threshold, FWE whole-brain corrected). In whole-brain voxel-level analyses, there were no significant differences between direct comparisons of fructose vs glucose sessions following correction for multiple comparisons. Fructose vs glucose ingestion resulted in lower peak levels of serum glucose (mean difference, 41.0 mg/dL [95% CI, 27.7-54.5]; P < .001), insulin (mean difference, 49.6 μU/mL [95% CI, 38.2-61.1]; P < .001), and glucagon-like polypeptide 1 (mean difference, 2.1 pmol/L [95% CI, 0.9-3.2]; P = .01).

CONCLUSION AND RELEVANCE: In a series of exploratory analyses, consumption of fructose compared with glucose resulted in a distinct pattern of regional CBF and a smaller increase in systemic glucose, insulin, and glucagon-like polypeptide 1 levels.


The study is small but creates a significant impact in trying to understand the epidemic of obesity since the introduction of fructose as a cheaper sweetener for commercially available foods especially drinks.

The study triggers the question whether intake of fructose containing foods entice individuals to eat more before getting full.

If one looks at the drinks or foods containing the highest level of fructose, one would practically see… the number one on the list are the carbonated colas followed closely by all different kinds of juices…

One can therefore assume that as more and more kids start to drink colas and juices…the more and more they get obese…the more difficult it is for them to lose weight during adulthood.

So what do I suggest?

Dont believe in ads that tell you drinking an orange juice that contains carnitine can make you lose weight!!! Remember…calories are calories as juices are juices in whatever form they come.  If you literally want to control your weight, then one simple advise is for you to eliminate juices in your diet and try to consume drinks that contain no  fructose or better yet water.

The only fructose that I recommend for us to enjoy are those coming from eating a fruit.

Be Vigilant before you DRINK… Read the Labels!!!

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: