Comments on: The Truth Of The Avandia Scare… http://docgerrytan.com/2007/05/31/the-truth-of-the-avandia-scare/ www.docgerrytan.com Wed, 08 Feb 2012 20:59:49 +0000 hourly 1 http://wordpress.com/ By: The FDA Ruling on Avandia… « That Health Rules http://docgerrytan.com/2007/05/31/the-truth-of-the-avandia-scare/#comment-18105 Wed, 01 Aug 2007 00:14:28 +0000 http://healthwealth.wordpress.com/2007/05/31/the-truth-of-the-avandia-scare/#comment-18105 [...] The Truth About The Avandia Scare [...]

]]> By: MM http://docgerrytan.com/2007/05/31/the-truth-of-the-avandia-scare/#comment-12435 Thu, 31 May 2007 09:32:22 +0000 http://healthwealth.wordpress.com/2007/05/31/the-truth-of-the-avandia-scare/#comment-12435 Dr — thank you for keeping patients informed. BTW, I looove the other posts here! Very helpful!!! Health is wealth ;)

]]> By: Doc Gerry http://docgerrytan.com/2007/05/31/the-truth-of-the-avandia-scare/#comment-12324 Thu, 31 May 2007 03:12:27 +0000 http://healthwealth.wordpress.com/2007/05/31/the-truth-of-the-avandia-scare/#comment-12324 A friend of mine sent me this email form the online publication of Lancet: the counterpart journal of NEJM in Europe.

Here’s the latest from the Lancet: You can access it thru this address: http://multimedia.thelancet.com/pdf/rosiglitazone_response.pdf
Key data points include:

The recent meta-analysis published in New England Journal of Medicine, which has been widely cited in media reports, inexplicably omitted the total percentage number of events. The actual number of heart attacks represents a very low frequency of events (0.6% of the more than 26,000 patients studied) and the difference in rates of heart attacks between Avandia and controls is less than 0.1%

Further analyses from ADOPT and DREAM – two long-term prospective clinical trials – show that the incidence of ischaemic cardiovascular events with Avandia is comparable to the two gold standard medicines (metformin or a sulphonylurea) used to treat type 2 diabetes (ADOPT) or to placebo (DREAM).

Findings from a soon-to-be-published, real-world study of more than 30,000 diabetes patients in a managed care database in the USA show the incidence of hospitalisations for heart attack, and/or for a surgery known as revascularisation for patients on Avandia is the same as for other diabetes treatments. These data are available on line on the clinical trials register.

The independent safety monitoring board for the RECORD trial – a large, long-term clinical trial, which has been designed to look at cardiovascular outcomes in patients with type 2 diabetes – reviewed an interim analysis of cardiovascular endpoints in all study participants, and determined that the study should be allowed to continue.

To summarise, data from long-term, large-scale, prospective clinical trials show that the overall ischaemic cardiovascular safety profile, including cardiovascular death, among patients treated with Avandia is comparable to patients treated with two other widely used diabetes medicines.

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